By John Halamka and Paul Cerrato — The Oxford Dictionary says disease is a disorder of structure or function, especially one that has a known cause and a distinctive group of symptoms, signs, or anatomical changes. It’s time to rethink that simplistic definition.

By John Halamka and Paul Cerrato — In part one, we discussed the shortcomings of evidence-based medicine and the disconnect between RCTs and bedside clinical care. Part 2 explores possible solutions, including machine learning-based algorithms. 

By John Halamka and Paul Cerrato — Evidence-based medicine has benefited patients in countless ways, but there’s a disconnect between EBM and the clinical care that is typically delivered at the bedside. Pragmatic, real-world trials and AI-based algorithms may help solve the problem.

A patient with a rare cancer found hope thanks to his dedicated physician at Minnesota Oncology and the Mayo Clinic Care Network.

By John Halamka and Paul Cerrato — In part 2 of our series on the basics of digital technology, we explore the deep learning tools that can improve medical image analysis and much more.

By John Halamka and Paul Cerrato — In this new series, we pull back the curtain on the Wizard of Oz to provide plain English explanations about machine learning, artificial neural networks, natural language processing, large language models, and related technology.

By John Halamka and Paul Cerrato — Given their tendency to invent “facts,” several researchers have begun comparing their strengths and weaknesses.

By John Halamka and Paul Cerrato—A well-reasoned, coherent thesis is not enough to convince editorial gatekeepers to accept your article. Consider these additional suggestions.

Mayo Clinic's Cancer CARE Beyond Walls program, launched in 2023, has provided over 200 chemotherapy treatments at home and plans to expand, offering clinical trials and virtual nurse support for patients in Florida while aiming to bring the service to additional locations.

By John Halamka and Paul Cerrato — Mayo Clinic’s Tapestry Study has demonstrated that next generation genetic analysis can have a significant impact on patient care.

Against the backdrop of the 43rd Annual J.P. Morgan Healthcare Conference, Mayo Clinic announced the formation of Mayo Clinic Digital Pathology, designed on a platform architecture to boldly unlock the power of its extensive archive of digital slides to revolutionize pathology and accelerate medical breakthroughs.

By John Halamka and Paul Cerrato — Imagine if you could create a digital clone of yourself that can be used to test various treatment options to determine which one is best for your real self.